目的研究N-芳基(芳基偶氮-1，3，4-噻二唑)磺酰胺类化合物的合成方法及抗癌活性。方法以芳胺、水杨醛、氨基硫脲和苯磺酰氯为原料合成相应的目标化合物，采用MTT法研究了目标化合物体外抑制L1210和B16癌细胞的活性。结果合成了一系列新型的N-芳基(芳基偶氮-1，3，4-噻二唑)磺酰胺类化合物，其结构经元素分析、IR、MS及1H-NMR确证。化合物5a，5g表现出明显的体外抗癌活性。结论N-芳基(芳基偶氮-1，3，4-噻二唑)磺酰胺类化合物有可能成为新型结构的抗癌药物。
Abstract
OBJECTIVE To study the synthesis and antitumor activity of N-aryl(arylazo-1,3,4-thiadiazoles)sulfonamides derivatives. METHODS The title compounds were synthesized by the condensation reaction of aromatic amine, salicylaldehyde, thiosemicarbazide and benzene sulfochloride, and their antitumor activities against L1210 and B16 cells were assayed by MTT method. RESULTS A series of novel N-aryl(arylazo-1,3,4-Thiadiazoles)sulfonamides derivatives were synthesized, and their structures were confirmed by IR, MS, 1H-NMR and elemental analysis. Compounds 5a and 5g showed potential antitumor activity. CONCLUSION N-aryl(arylazo-1,3,4-thiadiazoles)sulfonamides derivatives may be useful antitumor candidate drugs.
关键词
1 /
3 /
4-噻二唑 /
合成 /
抗癌活性
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Key words
1,3,4-thiadiazole /
synthesis /
antitumor activity
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中图分类号：
R914
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参考文献
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脚注
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基金
湖北省自然科学基金项目(2012FFB01103)
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